Platelet-Rich Plasma in Melasma-A Systematic Review

Area of Science:

• Dermatology
• Regenerative Medicine

Background:

• Melasma is a prevalent, recurrent hyperpigmentation disorder known for treatment resistance.
• Platelet-rich plasma (PRP) is an emerging therapeutic option with applications in various dermatological conditions.
• PRP has demonstrated potential efficacy in managing melasma.

Purpose of the Study:

• To systematically review existing literature on the effectiveness and safety of PRP for melasma treatment.
• To evaluate PRP's role as a standalone or adjunctive therapy for hyperpigmentation disorders.

Main Methods:

• A systematic review of published studies investigating PRP for melasma.
• Analysis of seven studies focusing on intradermal PRP injections and microneedling-assisted delivery.
• Assessment of study outcomes regarding melasma improvement and adverse events.

Main Results:

• Most studies reported significant melasma improvement with intradermal PRP injections.
• Microneedling combined with PRP showed positive outcomes for melasma.
• Limited evidence suggests no additional benefit of PRP when used with topical tranexamic acid or intense pulsed light in certain contexts.

Conclusions:

• Platelet-rich plasma (PRP) offers a viable treatment option for melasma through mechanisms inhibiting melanin synthesis.
• PRP demonstrates a moderate grade of recommendation for melasma treatment.
• Further research may clarify optimal protocols and combination therapies for melasma management with PRP.