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Updated: Oct 10, 2025

A Mimic of the Tumor Microenvironment: A Simple Method for Generating Enriched Cell Populations and Investigating Intercellular Communication
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Published on: September 20, 2016

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Pulling the Strings of the Tumor Microenvironment

Claudia Burrello1, Karin E de Visser2,3

  • 1Division of Tumor Biology and Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands.

Cancer Immunology Research
|December 16, 2021
PubMed

Insights

Targeting macrophages in cancer immunotherapy can reprogram the tumor microenvironment. This strategy promotes a coordinated antitumor immune response, offering a novel approach for lung carcinoma treatment.

Area of Science:

  • Immunology
  • Cancer Research
  • Tumor Microenvironment

Background:

  • Macrophages play a critical role in cancer, often exhibiting protumorigenic functions.
  • Understanding macrophage behavior is key to developing effective cancer immunotherapies.

Purpose of the Study:

  • To investigate the impact of macrophage targeting on the tumor microenvironment.
  • To determine if modulating macrophages can induce an antitumorigenic immune response.

Main Methods:

  • Utilized a lung carcinoma mouse model.
  • Employed strategies to target macrophages within the tumor microenvironment.

Main Results:

  • Macrophage targeting was shown to significantly influence the tumor microenvironment.
  • This manipulation led to a coordinated and effective antitumorigenic immune reaction.

Conclusions:

  • Targeting macrophages is a viable strategy to reprogram the tumor microenvironment for cancer immunotherapy.
  • This approach holds promise for enhancing antitumor immunity in lung carcinoma.

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