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Dynamics in Controllable Stimuli-Responsive Self-Assembly of Polymer Vesicles with Stable Radical Functionality.
Md Alim Uddin1, Haojie Yu1, Li Wang1
1State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, Zhejiang P. R. China.
ACS Applied Materials & Interfaces
|December 16, 2021
Summary
Researchers developed novel polymer vesicles for drug delivery, using electron paramagnetic resonance (EPR) spectroscopy to study their dynamics. These smart nanosystems show promise for targeted cancer treatment with high drug loading and controlled release.
Area of Science:
- Polymer Science
- Materials Science
- Nanotechnology
Background:
- Stimuli-responsive polymer vesicles are promising for drug delivery.
- Understanding polymer dynamics in these systems is crucial for structure-property relationships.
- Pendant functional groups influence vesicle behavior under varying conditions.
Purpose of the Study:
- To synthesize nitroxide radical-containing copolymers for investigating dynamics in vesicular assemblies.
- To explore the structure-property relationships of these polymers under different physicochemical conditions.
- To evaluate the potential of these vesicles as anticancer drug carriers.
Main Methods:
- Synthesis of nitroxide radical-containing copolymers.
- Electron paramagnetic resonance (EPR) spectroscopy to study local dynamics and supramolecular structure.
- Cellular experiments to assess biocompatibility and anticancer activity.
Main Results:
- EPR spectroscopy revealed stimuli-responsive polymer chain dynamics dependent on the microenvironment.
- Vesicles demonstrated high drug loading efficiency (63.65%) and accelerated drug release upon reduction.
- The nanosystems exhibited good biocompatibility and anticancer activity against HeLa cells.
Conclusions:
- Developed controllable, stimuli-responsive polymer nanosystems for drug delivery.
- Demonstrated the utility of EPR spectroscopy in understanding polymer vesicle dynamics.
- Highlighted the potential of these nanosystems for effective cancer treatment.
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