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Patch testing with the Japanese baseline series 2015: A 4-year experience.
Akiko Ito1,2, Kayoko Suzuki2,3, Kayoko Matsunaga2,4
1Department of Dermatology, Nagata Clinic, Niigata, Japan.
Contact Dermatitis
|December 18, 2021
Summary
The Japanese baseline series (JBS) 2015 patch test identified gold sodium thiosulfate and nickel sulfate as the most common sensitizers. This modified TRUE test is effective for widespread allergy testing in Japan.
Area of Science:
- Dermatology
- Allergology
- Epidemiology
Background:
- The Japanese baseline series (JBS) for patch testing was established in 1994 and updated in 2008 and 2015.
- The JBS 2015 is a modified version of the thin-layer rapid-use epicutaneous (TRUE) test.
- No prior nationwide studies on the TRUE test in Japan were reported.
Purpose of the Study:
- To determine the prevalence of allergic sensitizations to the allergens included in the JBS 2015.
- To assess the utility of the modified TRUE test for nationwide patch testing.
Main Methods:
- Utilized the web-registered Skin Safety Care Information Network (SSCI-Net) database.
- Analyzed patch test results from 63 facilities between April 2015 and March 2019.
- Included data from 5865 patients.
Main Results:
- Gold sodium thiosulfate (GST) and nickel sulfate showed the highest positivity rates at 25.7% and 24.5%, respectively.
- Urushiol (9.1%), p-phenylenediamine (PPD; 8.9%), and cobalt chloride (8.4%) were also significant allergens.
- Low positivity rates were observed for mercaptobenzothiazole (0.8%) and formaldehyde (0.9%).
Conclusions:
- Nickel sulfate and GST were the most frequent causes of allergic contact dermatitis in the study population.
- The JBS 2015, incorporating the modified TRUE test, is a suitable tool for baseline patch testing in Japan.
- The findings provide valuable data on allergen prevalence for dermatologists and public health initiatives.
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