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Current and Potential Therapies Targeting Inflammation in NASH.
Somaya Albhaisi1, Mazen Noureddin2
1Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, United States.
Frontiers in Endocrinology
|December 20, 2021
Summary
Nonalcoholic steatohepatitis (NASH), an advanced liver condition, involves inflammation driven by internal and external factors. Understanding these triggers is key to developing new therapies for NASH.
Area of Science:
- Hepatology
- Immunology
- Gastroenterology
Background:
- Nonalcoholic steatohepatitis (NASH) is the advanced stage of nonalcoholic fatty liver disease (NAFLD).
- NASH is defined by liver cell fat accumulation, inflammation, injury, and fibrosis.
- Inflammation is a critical driver of NASH progression, originating from both within the liver and from extrahepatic sources like adipose tissue and the gut.
Purpose of the Study:
- To review current and emerging therapies targeting inflammation in NASH.
- To highlight the importance of identifying inflammation triggers for NASH treatment strategies.
Main Methods:
- Literature review of current research on NASH pathogenesis and treatment.
- Analysis of studies focusing on inflammatory pathways in NASH.
- Synthesis of information on therapeutic targets for inflammation in NASH.
Main Results:
- Inflammation is a central mechanism in NASH development and progression.
- Both intrahepatic factors (lipotoxicity, oxidative stress) and extrahepatic sources (gut microbiota, adipose tissue) contribute to NASH inflammation.
- Targeting inflammation presents a promising therapeutic avenue for NASH.
Conclusions:
- Identifying and targeting the triggers of inflammation is crucial for developing effective NASH therapies.
- Therapeutic strategies aimed at reducing inflammation hold potential for halting or reversing NASH progression.
- Further research into the complex inflammatory network in NASH is warranted to optimize treatment outcomes.
Keywords:
cytokineshepatocellular injuryinflammationlymphocytesmacrophagesnon-alcoholic steatohepatitisoxidative stresstreatmentMore Related Videos
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