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Overview of Exosomes

Overview of Exosomes

Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...

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Related Experiment Video

Updated: Oct 9, 2025

Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool

Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool

Published on: May 27, 2016

Microfluidic-Based Exosome Analysis for Liquid Biopsy.

Bingqian Lin¹, Yanmei Lei², Junxia Wang¹

¹The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory of Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.

|December 20, 2021

Summary

This summary is machine-generated.

Microfluidics technology enhances liquid biopsy by enabling precise isolation and molecular detection of exosomes, crucial biomarkers for cancer detection and precision medicine. This approach overcomes challenges in exosome analysis for improved patient care.

Keywords:

exosomes detection exosomes isolation liquid biopsy microfluidic chips

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An Innovative Method for Exosome Quantification and Size Measurement

An Innovative Method for Exosome Quantification and Size Measurement

Published on: January 17, 2015

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Last Updated: Oct 9, 2025

Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool

Exosomal miRNA Analysis in Non-small Cell Lung Cancer NSCLC Patients' Plasma Through qPCR: A Feasible Liquid Biopsy Tool

Published on: May 27, 2016

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes

Published on: May 24, 2019

An Innovative Method for Exosome Quantification and Size Measurement

An Innovative Method for Exosome Quantification and Size Measurement

Published on: January 17, 2015

Area of Science:

Biotechnology
Nanotechnology
Molecular Diagnostics

Background:

Liquid biopsy offers non-invasive molecular profiling for precision medicine.
Exosomes are key biomarkers in liquid biopsy, linked to cancer pathogenesis.
Challenges exist in isolating and characterizing heterogeneous exosomes from biofluids.

Purpose of the Study:

To review advancements in microfluidics for exosome isolation and molecular detection.
To highlight the characterization of exosomal biomarkers in cancer liquid biopsy.
To discuss challenges and future perspectives in microfluidics-based exosome research.

Main Methods:

Review of state-of-the-art microfluidics-based technologies for exosome research.
Focus on in situ exosome capture and molecular detection strategies.
Analysis of microfluidic approaches for biomarker characterization.

Main Results:

Microfluidics provides precise fluid manipulation for efficient exosome isolation.
Recent advances enable high selectivity and sensitivity in exosome capture and detection.
Microfluidics facilitates the molecular characterization of exosomes for cancer diagnostics.

Conclusions:

Microfluidics technology is revolutionizing exosome-based liquid biopsy.
This approach addresses key challenges in exosome isolation and analysis.
Future microfluidic systems hold promise for enhanced cancer liquid biopsy applications.