Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

2.9K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.9K
Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

3.9K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
3.9K
Overview of Secretory Vesicles01:33

Overview of Secretory Vesicles

8.8K
Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
8.8K
Cardiovascular Drugs: Classification based on Therapeutic Indications01:18

Cardiovascular Drugs: Classification based on Therapeutic Indications

3.4K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
3.4K
Overview of the Vascular System01:20

Overview of the Vascular System

3.1K
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
3.1K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

76
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
76

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Low fluid shear stress stimulates the uptake of noxious endothelial extracellular vesicles via MCAM and PECAM-1 cell adhesion molecules.

Journal of extracellular vesicles·2024
Same author

Hepatocyte-derived biomarkers predict liver-related events at 2 years in Child-Pugh class A alcohol-related cirrhosis.

Journal of hepatology·2023
Same author

Cell-specific targeting of extracellular vesicles through engineering the glycocalyx.

Journal of extracellular vesicles·2022
Same author

Role of extracellular vesicles in atherosclerosis: An update.

Journal of leukocyte biology·2021
Same author

Messages from the heart.

European heart journal·2021
Same author

Extracellular Mitochondria and Vesicles.

Circulation research·2019

Related Experiment Video

Updated: Oct 9, 2025

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
05:30

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

657

[Extracellular vesicles and cardiovascular diseases].

Pierre-Michael Coly1, Xavier Loyer1

  • 1Université de Paris, Inserm UMR 970, Paris-Centre de recherche cardiovasculaire (Paris-Cardiovascular Research Center), 56 rue Leblanc, F-75015 Paris, France.

Medecine Sciences : M/S
|December 20, 2021
PubMed
Summary

Extracellular vesicles (EVs) are key to intercellular communication in cardiovascular diseases. This review explores their dual role in disease and potential as diagnostic and therapeutic tools.

More Related Videos

Evaluation of the Storage Stability of Extracellular Vesicles
11:31

Evaluation of the Storage Stability of Extracellular Vesicles

Published on: May 22, 2019

14.5K
Uptake of Fluorescent Labeled Small Extracellular Vesicles In Vitro and in Spinal Cord
09:01

Uptake of Fluorescent Labeled Small Extracellular Vesicles In Vitro and in Spinal Cord

Published on: May 23, 2021

3.8K

Related Experiment Videos

Last Updated: Oct 9, 2025

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies
05:30

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

657
Evaluation of the Storage Stability of Extracellular Vesicles
11:31

Evaluation of the Storage Stability of Extracellular Vesicles

Published on: May 22, 2019

14.5K
Uptake of Fluorescent Labeled Small Extracellular Vesicles In Vitro and in Spinal Cord
09:01

Uptake of Fluorescent Labeled Small Extracellular Vesicles In Vitro and in Spinal Cord

Published on: May 23, 2021

3.8K

Area of Science:

  • Cardiovascular Medicine
  • Cell Biology
  • Biotechnology

Background:

  • Cardiovascular diseases (CVDs) are a leading global cause of mortality, necessitating novel therapeutic and diagnostic strategies.
  • Extracellular vesicles (EVs) mediate intercellular communication and are implicated in cardiovascular pathophysiology.
  • The role of EVs in CVDs is complex, varying with their origin and cargo, presenting both challenges and opportunities.

Purpose of the Study:

  • To review recent advancements in understanding the role of extracellular vesicles (EVs) in cardiovascular pathologies.
  • To highlight the potential of EVs as diagnostic biomarkers and therapeutic agents for cardiovascular diseases.

Main Methods:

  • Literature review of recent research on extracellular vesicles and cardiovascular diseases.
  • Analysis of studies investigating EV function in inflammation, angiogenesis, and other CVD-related pathways.
  • Synthesis of findings on the dual role of EVs (deleterious vs. therapeutic) in cardiovascular contexts.

Main Results:

  • Extracellular vesicles (EVs) actively regulate key cardiovascular pathways, including inflammation and angiogenesis.
  • EVs exhibit a context-dependent role in cardiovascular diseases, influenced by their source and molecular contents.
  • Emerging evidence supports the use of EVs as promising diagnostic biomarkers and therapeutic agents for CVDs.

Conclusions:

  • Extracellular vesicles (EVs) are pivotal in cardiovascular disease development and progression.
  • Targeting or utilizing EVs offers innovative avenues for cardiovascular disease diagnosis and treatment.
  • Further research into EV biology is crucial for unlocking their full clinical potential in cardiology.