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Activatable fluorogenic probe for accurate imaging of ulcerative colitis hypoxia in vivo
Mingrui Li1, Yong Zhang1, Xiaojun Ren1
1Department of Chemistry and Biology, Faculty of Environment and Life Science, Beijing University of Technology, Beijing, 100124, P. R. China. xjren@bjut.edu.cn.
Chemical Communications (Cambridge, England)
|December 20, 2021
Abstract:
A simple but efficient fluorogenic probe is reported for accurate imaging of ulcerative colitis via hypoxia detection. The hypoxia produced by ulcerative colitis can lead to the upregulation of nitroreductase (NTR). NB-NO2 provides a unique response to NTR, enabling accurate imaging of Dextran sulphate sodium (DSS)-induced ulcerative colitis in vivo.
