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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jun 8, 2026

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
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Published on: February 3, 2015

Controlled In Situ Self-Assembly for Pretargeted Tumor Theranostics via Bioorthogonal Activation.

Pan Liang1, Kai Cao1, Shaoqing Xiong1,2

  • 1Department of Chemistry, Beijing University of Technology, Beijing, P. R. China.

Advanced Healthcare Materials
|June 7, 2026
PubMed
Summary

This study introduces a novel platform for cancer phototheranostics, combining fluorescence imaging and photodynamic therapy (PDT). The system uses tumor-specific self-assembly and bioorthogonal activation for precise, targeted cancer treatment with reduced toxicity.

Keywords:
bioorthogonal chemistryin situ self‐assemblyphotodynamic therapyphototheranostic probetarget cancer imaging

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Last Updated: Jun 8, 2026

Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging
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Published on: February 3, 2015

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Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Phototheranostic agents integrate imaging and therapy but face challenges with specificity and pharmacokinetics.
  • Nonspecific activation and poor control limit the precision of current cancer theranostic approaches.

Purpose of the Study:

  • To develop an ultra-specific, in situ activatable platform for precise tumor phototheranostics.
  • To enhance spatiotemporal control in cancer treatment by combining pretargeting and bioorthogonal activation.

Main Methods:

  • Designed a dual-responsive pretargeting agent (CBT-Tz) that self-assembles in the tumor microenvironment.
  • Utilized a bioorthogonal reaction between tetrazine (Tz) and vinyl ether-caged hemicyanine (PEG-hCy-VE) for activation.
  • Integrated in situ self-assembly with bioorthogonal activation for controlled drug delivery and therapy.

Main Results:

  • Achieved localized accumulation of Tz groups via tumor-triggered self-assembly.
  • Restored near-infrared fluorescence and activated potent photodynamic therapy (PDT) selectively at the tumor site.
  • Demonstrated effective tumor suppression with minimal systemic toxicity through real-time imaging-guided personalized PDT.

Conclusions:

  • The developed platform offers robust, extensible, and highly specific capabilities for precise drug delivery.
  • Synergistic in situ self-assembly and bioorthogonal activation enable precise theranostics for heterogeneous tumors.
  • This approach provides superior spatiotemporal control for simultaneous high-contrast imaging and spatially precise PDT.