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Updated: Oct 9, 2025

Determining the Ice-binding Planes of Antifreeze Proteins by Fluorescence-based Ice Plane Affinity
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Determining the Ice-binding Planes of Antifreeze Proteins by Fluorescence-based Ice Plane Affinity

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Diffusion Attachment Model for Long Helical Antifreeze Proteins to Ice.

Kartik Kamat1, Pavithra M Naullage2, Valeria Molinero2

  • 1Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, California 93106, United States.

Biomacromolecules
|December 20, 2021
PubMed
Summary

Antifreeze proteins (AFPs) bind ice, but most orientations are blocked. This study reveals how restricted AFP orientations create an entropic barrier, slowing ice binding and impacting biological environments.

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