Related Experiment Video
Updated: Oct 9, 2025

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
Published on: August 24, 2019
Incidental Findings of Appendiceal Diverticulitis Presenting as Acute Appendicitis
Benjamin Souferi1, Kristin Sheppard1, Ayolola O Onayemi1
1Department of Surgery, Hackensack Meridian Health, 14331Palisades Medical Center, North Bergen, NJ, USA.
Abstract:
Diverticulosis of the appendix (DA) is a rare pathological finding that clinically imitates acute appendicitis and is most commonly found in adult males with chronic abdominal pain. It has a higher rate of perforation compared to acute appendicitis (84% vs 12%, P<0.01), and is consequently associated with a higher rate of mortality. Appendiceal diverticulitis has been found to have a significant association with incidental appendiceal neoplasms, therefore elective prophylactic appendectomy is recommended to prevent the risk of complications and to rule out the possibility of a coexisting neoplasm. Meticulous gross examination in addition to thorough histological examination of the entire appendectomy specimen by pathologists is essential in order to identify diverticula. We present two female patients with signs and symptoms consistent with acute appendicitis, they were found to have appendiceal diverticulitis on pathologic evaluation.
Insights
Diverticulosis of the appendix (DA) is a rare condition mimicking appendicitis, with higher perforation and mortality rates. Early diagnosis and prophylactic appendectomy are crucial for preventing complications and ruling out neoplasms.
Area of Science:
- Gastroenterology
- Pathology
Background:
- Diverticulosis of the appendix (DA) is a rare condition.
- It often presents with symptoms similar to acute appendicitis.
- DA is more prevalent in adult males with chronic abdominal pain.
Purpose of the Study:
- To highlight the clinical presentation and pathological findings of appendiceal diverticulitis.
- To emphasize the increased risk of perforation and mortality associated with DA.
- To underscore the importance of prophylactic appendectomy in managing DA.
Main Methods:
- Case report of two female patients presenting with acute appendicitis-like symptoms.
- Pathological evaluation of appendectomy specimens.
- Review of existing literature on diverticulosis of the appendix.
Main Results:
- Both patients were diagnosed with appendiceal diverticulitis post-operatively.
- Diverticulosis of the appendix has a significantly higher perforation rate (84%) than acute appendicitis (12%).
- A significant association exists between appendiceal diverticulitis and incidental appendiceal neoplasms.
Conclusions:
- Appendiceal diverticulitis requires meticulous pathological examination for accurate diagnosis.
- Prophylactic appendectomy is recommended to prevent complications and detect coexisting neoplasms.
- This condition, though rare, necessitates consideration in the differential diagnosis of acute appendicitis.
Related Concept Videos
Appendicitis-I: Introduction
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Appendicitis-II: Diagnostic Studies and Management
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Acute Pancreatitis II: Clinical Manifestations and Management
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:

