Related Experiment Video
Updated: Oct 9, 2025
05:56
Demonstrating a Linear Relationship Between Vascular Endothelial Growth Factor and Luteinizing Hormone in Kidney Cortex Extracts
Published on: January 22, 2020
4.9K
Growth Hormone and IGF1 Actions in Kidney Development and Function.
Evgenia Gurevich1, Yael Segev2, Daniel Landau1,3
1Department of Nephrology, Schneider Children's Medical Center of Israel, 14 Kaplan Street, Petach Tikva 4920235, Israel.
Cells
|December 24, 2021
Summary
Growth hormone (GH) and insulin-like-growth factor-1 (IGF-1) significantly impact kidney function and development. Alterations in the GH/IGF-1 axis are linked to chronic kidney disease (CKD) complications in children.
Area of Science:
- Nephrology
- Endocrinology
- Pediatrics
Background:
- The growth hormone (GH)/insulin-like-growth factor-1 (IGF-1) system is crucial for kidney development and function.
- This system regulates glomerular hemodynamics and tubular handling of water, sodium, phosphate, and calcium.
Purpose of the Study:
- To explore the role of the GH/IGF-1 axis in kidney development, function, and disease.
- To understand the implications of GH/IGF-1 alterations in pediatric chronic kidney disease (CKD).
Main Methods:
- Review of transgenic animal models to study GH excess effects on the kidney.
- Analysis of the GH/IGF-1 axis in the context of diabetic nephropathy and kidney hypertrophy.
- Investigation of GH/IGF-1 axis alterations in children with CKD.
Main Results:
- GH excess, but not IGF-1, can induce hyperfiltration, albuminuria, and glomerulosclerosis in animal models.
- The GH/IGF-1 system is implicated in the pathogenesis of diabetic nephropathy and compensatory kidney hypertrophy.
- Children with CKD exhibit altered GH/IGF-1 axis, leading to growth retardation and GH resistance.
Conclusions:
- The GH/IGF-1 axis is a critical regulator of kidney physiology and pathophysiology.
- GH resistance and inflammation contribute to growth failure in pediatric CKD.
- Prolonged recombinant human GH (rhGH) treatment may be safe for managing short stature in children with CKD.
Related Concept Videos
01:33Hormonal Regulation
34.0K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
34.0K
01:13Introduction to Urinary System
4.6K
The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
4.6K
01:17Hormones and Bone Tissue
3.1K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.1K
01:28Glomerular Filtration Rate and its Regulation
3.5K
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
3.5K
01:24Regulation of Angiogenesis and Blood Supply
2.8K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.8K
01:28Role of Hematopoietic Growth Factors
1.8K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
1.8K