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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Related Experiment Video

Updated: Oct 9, 2025

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Amyotrophic Lateral Sclerosis: A Diet Review.

Salvatore D'Antona1, Martina Caramenti1, Danilo Porro1

  • 1Institute of Bioimaging and Molecular Physiology, National Research Council (IBFM-CNR), Via F.lli Cervi 93, 20054 Milan, Italy.

Foods (Basel, Switzerland)
|December 24, 2021
PubMed
Summary

Diet significantly impacts amyotrophic lateral sclerosis (ALS) risk. Antioxidant-rich diets may reduce risk, while high-fat diets may increase it, though research is ongoing.

Keywords:
amyotrophic lateral sclerosisdieteating behaviourmicrobiotamotor neuron degeneration

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Area of Science:

  • Neuroscience
  • Nutritional Science
  • Epidemiology

Background:

  • Amyotrophic lateral sclerosis (ALS) involves motor neuron degeneration with unclear causes.
  • Dietary factors like oxidative stress may influence ALS onset.
  • Specific dietary components are linked to altered ALS risk.

Purpose of the Study:

  • To review the relationship between diet, microbiota, and metabolic diseases in ALS.
  • To explore how nutritional interventions might affect ALS progression.
  • To highlight the need for further research into diet's role in ALS.

Main Methods:

  • Literature review of epidemiological studies on ALS and diet.
  • Analysis of research on dietary components (antioxidants, fats) and ALS risk.
  • Examination of studies on microbiota and metabolic alterations in ALS.

Main Results:

  • Conflicting data exists regarding diet's influence on ALS risk.
  • High-fat and glutamate intake may increase ALS risk.
  • Antioxidant-rich diets show potential for risk reduction, but evidence is inconsistent.

Conclusions:

  • Dietary interventions and understanding metabolic changes are crucial for ALS research.
  • Further studies are needed to clarify diet's role in ALS onset and progression.
  • Microbiota and metabolic diseases are potential factors in ALS pathogenesis.