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Related Concept Videos

CRISPR and crRNAs02:53

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Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
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CRISPR/Cas9 Genome Editing01:28

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The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
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CRISPR01:59

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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
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CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
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Visualization Analysis of CRISPR Gene-editing Knowledge Map based on Citespace.

Can Gao1,2, Rui Wang2, Lin Zhang3

  • 1Yan'an Key Laboratory of Microbial Drug Innovation and Transformation, School of Basic Medicine, Yan'an University, 716000 Yan'an, Shaanxi China.

Biology Bulletin of the Russian Academy of Sciences
|December 27, 2021
PubMed
Summary
This summary is machine-generated.

CRISPR gene-editing technology shows rapidly increasing publications, with the USA leading research. Key applications are emerging in animals, plants, and clinical treatments, highlighting its growing impact.

Keywords:
CRISPRCiteSpaceGene-editingVisualization analysis

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Area of Science:

  • Biotechnology
  • Genetics
  • Molecular Biology

Background:

  • CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a bacterial immune system repurposed for gene editing.
  • Gene editing technologies offer unprecedented control over genetic material.

Purpose of the Study:

  • To analyze the research landscape of CRISPR gene-editing technology.
  • To identify publication trends, leading institutions, and key research frontiers.

Main Methods:

  • Bibliometric analysis using the Web of Science database.
  • Visualization of literature data with CiteSpace IV software.

Main Results:

  • A consistent year-over-year increase in publications related to CRISPR gene editing.
  • The USA leads in publication volume, followed by China, though China's research centrality is low.
  • Prominent contributions identified from Doudna JA and Zhang F.
  • Strong internal collaborations within countries but limited international research links.
  • Emerging research hotspots include applications in animals, plants, detection, diagnosis, and clinical treatment.

Conclusions:

  • CRISPR gene-editing research is rapidly expanding globally.
  • Strategic international collaborations are needed to advance the field.
  • The technology holds significant promise for diverse applications in agriculture, medicine, and diagnostics.