Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However, invadopodia can...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A rapid transfer of virions coated with heparan sulfate from the ECM to CD151 defines an early step in the human papillomavirus infection cascade.

eLife·2026
Same author

The MYB-related transcription factor MYPOP acts as a selective regulator of cancer cell growth.

Communications biology·2026
Same author

[Differences between women and men in rheumatic systemic diseases with lung involvement].

Pneumologie (Stuttgart, Germany)·2026
Same author

Respiratory Muscle Strength in Rheumatoid Arthritis.

Journal of clinical medicine·2025
Same author

Pulmonary Involvement in Patients with Positive Myositis Antibodies in Rheumatology: A Retrospective Monocentric Analysis.

Journal of clinical medicine·2025
Same author

[Frequency of interstitial lung diseases in inpatient rheumatology : Retrospective analysis of inpatient diagnoses 2005-2023 in Germany].

Zeitschrift fur Rheumatologie·2025

Related Experiment Video

Updated: Jun 23, 2026

In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells
09:20

In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells

Published on: July 23, 2010

15.9K

HPV16 Entry into Epithelial Cells: Running a Gauntlet.

Snježana Mikuličić1, Johannes Strunk1, Luise Florin1

  • 1Institute for Virology and Research Centre for Immunotherapy (FZI), University Medical Centre of the Johannes Gutenberg-University Mainz, Obere Zahlbacher Strasse 67, 55131 Mainz, Germany.

Viruses
|December 28, 2021
PubMed
Summary

Human papillomaviruses (HPV) hijack host cell processes, utilizing mitosis for nuclear entry and replication. This review details HPV16

Keywords:
HPVHPV16L1L2endocytosishuman papillomavirusintrinsic immunityrestriction factortraffickingvirus entry

More Related Videos

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
13:41

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

Published on: March 8, 2012

12.6K
Generation of Organotypic Raft Cultures from Primary Human Keratinocytes
07:26

Generation of Organotypic Raft Cultures from Primary Human Keratinocytes

Published on: February 22, 2012

19.4K

Related Experiment Videos

Last Updated: Jun 23, 2026

In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells
09:20

In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells

Published on: July 23, 2010

15.9K
Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus
13:41

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

Published on: March 8, 2012

12.6K
Generation of Organotypic Raft Cultures from Primary Human Keratinocytes
07:26

Generation of Organotypic Raft Cultures from Primary Human Keratinocytes

Published on: February 22, 2012

19.4K

Area of Science:

  • Virology
  • Cell Biology
  • Molecular Biology

Background:

  • Human papillomaviruses (HPV) exhibit unique cellular trafficking mechanisms during infection.
  • Understanding HPV entry is crucial for developing antiviral strategies.

Purpose of the Study:

  • To elucidate the intricate nuclear import pathway of oncogenic HPV type 16.
  • To contrast host cell processes that promote or inhibit HPV infection.

Main Methods:

  • Review of existing literature on HPV cellular entry and trafficking.
  • Analysis of viral protein L1 and L2 roles in infection establishment.
  • Examination of host cell mitotic events exploited by HPV.

Main Results:

  • HPV utilizes clathrin-independent endocytosis and retrograde transport to the trans-Golgi network.
  • Mitotic cellular reorganization facilitates virion transport to the nucleus.
  • HPV manipulates PML nuclear bodies for viral transcription and replication.

Conclusions:

  • HPV exploits host cell mitosis, including Golgi fragmentation and nuclear envelope breakdown, for nuclear entry.
  • The viral capsid protein L2 is essential for mediating virus-cell interactions during entry.
  • This pathway allows HPV to evade intrinsic cellular immune defenses and establish infection.