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Updated: Oct 8, 2025

Global Identification of Co-Translational Interaction Networks by Selective Ribosome Profiling
Published on: October 7, 2021
The ISOTILT software for discovering cooperative rigid-unit rotations in networks of interconnected rigid units
Branton J Campbell1, Harold T Stokes1, Tyler B Averett1
1Physics and Astronomy, Brigham Young University, Provo, Utah 84602, USA.
Abstract:
A user-friendly web-based software tool called 'ISOTILT' is introduced for detecting cooperative rigid-unit modes (RUMs) in networks of interconnected rigid units (e.g. molecules, clusters or polyhedral units). This tool implements a recently described algorithm in which symmetry-mode patterns of pivot-atom rotation and displacement vectors are used to construct a linear system of equations whose null space consists entirely of RUMs. The symmetry modes are first separated into independent symmetry-mode blocks and the set of equations for each block is solved separately by singular value decomposition. ISOTILT is the newest member of the ISOTROPY Software Suite. Here, it is shown how to prepare structural and symmetry-mode information for use in ISOTILT, how to use each of ISOTILT's input fields and options, and how to use and interpret ISOTILT output.
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