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Epigenetic Regulation in Atherosclerosis

Chunli Wang1, Fei Wang1, Fang Liu1

  • 1Department of Geriatrics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.

Discovery Medicine
|December 29, 2021
PubMed

Insights

Epigenetics, including DNA methylation and histone modification, is crucial in atherosclerosis development. Understanding these epigenetic changes offers new targets for preventing and treating cardiovascular disease in the elderly.

Area of Science:

  • Cardiovascular Science
  • Epigenetics
  • Molecular Biology

Background:

  • Cardiovascular disease (CVD), particularly atherosclerosis, is a major health concern for the elderly.
  • Atherosclerosis, the underlying pathology of CVD, is increasingly linked to epigenetic dysregulation.
  • Epigenetic mechanisms like DNA methylation, histone modification, and non-coding RNAs are vital in cardiovascular health.

Purpose of the Study:

  • To review the latest advancements in epigenetic modifications.
  • To elucidate the role of epigenetics in the occurrence and progression of atherosclerosis.
  • To identify potential therapeutic targets for atherosclerosis based on epigenetic research.

Main Methods:

  • Literature review of recent studies on epigenetics and atherosclerosis.
  • Analysis of epigenetic mechanisms including DNA methylation, histone modification, and non-coding RNAs.
  • Synthesis of findings on the impact of epigenetic regulation on cardiovascular disease.

Main Results:

  • Epigenetic factors significantly influence heart development, stress response, and endothelial injury.
  • Abnormal epigenetic regulation is implicated as a cause of atherosclerosis.
  • Emerging research explores epigenetic modifications for novel drug development in CVD.

Conclusions:

  • Epigenetic mechanisms are central to the pathogenesis of atherosclerosis.
  • Further exploration of epigenetic pathways is necessary for understanding CVD.
  • Targeting epigenetic modifications presents promising avenues for atherosclerosis prevention and treatment.

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