Related Experiment Video
Updated: Oct 8, 2025

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
Published on: April 18, 2019
Comparison of Computerized Prescription Support Systems in COVID-19 Patients: INTERCheck and Drug-PIN
Antonio Martocchia1, Clara Bruscia1, Giulia Conforti1
1Sant'Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1032, 00189 Rome, Italy.
Computerized prescription support systems like INTERCheck® and Drug-PIN® aid in managing COVID-19 patients, especially those with comorbidities and polypharmacy. These tools help optimize drug prescriptions and patient care, particularly for the elderly.
Area of Science:
- Medical Informatics
- Clinical Pharmacology
- Infectious Diseases
Background:
- Coronavirus disease 2019 (COVID-19) poses significant mortality risks, particularly for individuals with multiple comorbidities and polypharmacy.
- Effective management of COVID-19 requires careful drug evaluation to minimize adverse drug reactions.
- Healthcare systems face substantial challenges in treating COVID-19 patients due to complex health profiles.
Purpose of the Study:
- To investigate the utility of computerized prescription support systems in managing and treating COVID-19 infection.
- To assess the effectiveness of INTERCheck® and Drug-PIN® in characterizing patients and improving drug prescriptions for COVID-19.
- To evaluate the impact of these systems on patient care, with a focus on the elderly population.
Main Methods:
- Evaluated 33 COVID-19 patients and 42 control subjects using INTERCheck® and Drug-PIN® software.
- Assessed comorbidity (number of pathologies), polypharmacy (number of drugs), and total INTERCheck scores.
- Analyzed the correlation between INTERCheck and Drug-PIN software scores at admission and during hospitalization.
Main Results:
- COVID-19 patients exhibited significantly higher comorbidity (5.8 ± 3.8) and INTERCheck scores (9.2 ± 7.1) compared to controls.
- A statistically significant correlation was found between INTERCheck and Drug-PIN software scores (p < 0.0000001 at admission; p < 0.00000001 during hospitalization).
- Both systems demonstrated utility in patient characterization and optimizing drug prescriptions for COVID-19.
Conclusions:
- Computerized prescription support systems, INTERCheck® and Drug-PIN®, are valuable tools for managing COVID-19 patients.
- These systems enhance the characterization of patients with COVID-19, particularly those with comorbidities and polypharmacy.
- Utilizing these tools can lead to improved drug prescriptions and better patient outcomes, especially in the elderly.
Related Concept Videos
Nursing Clinical Information System
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
Pharmacokinetics: Drug–Drug Interactions
Drug Products: Biologics, Biosimilars and Interchangeables
Pharmacokinetics: Drug–Food and Drug–Viral Interactions
Bioequivalence of Drugs: Drugs with Multiple Indications
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

