A Multi-Channel Stimulator With High-Resolution Time-to-Current Conversion for Vagal-Cardiac Neuromodulation

This paper presents a low power integrated multi-channel stimulator for a cardiac neuroprosthesis designed to restore the parasympathetic control after heart transplantation. The proposed stimulator is based on time-to-current conversion. It replaces the conventional current mode digital-to-analog converter (DAC) that uses tens of microamps for biasing, with a novel capacitor time-based DAC (CT-DAC) offering about 10-bit current amplitude resolution with a bias current of only 250 nA. A stimulator chip was designed in a 0.18 μm CMOS high-voltage (HV) technology. It consists of 16 independent channels, each capable of delivering up to 550 μA stimulus current with a HV output stage that can be operated up to 20 V. The stimulator chip performance was evaluated using both RC equivalent load and a microelectrode array in saline solution. It is power efficient, provides high-resolution current amplitude stimulation, and has good charge balance. The design is suitable for multi-channel neural stimulation applications.