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Updated: Oct 7, 2025
08:48
Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
Published on: April 21, 2022
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Abnormal sperm morphology is associated with sensitization to inhaled allergens
Rafał Adamczak1, Natalia Ukleja-Sokołowska2, Magdalena Pasińska3
1Department of Obstetrics, Gynecology and Oncology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland.
International Journal of Immunopathology and Pharmacology
|January 5, 2022
Summary
Inhalation allergies negatively impact male semen quality, specifically increasing sperm tail defects in those allergic to birch, rye, cat, alder, and grass. Further research is needed to understand the immunological links.
Area of Science:
- Reproductive immunology
- Environmental health
Background:
- Allergies involve a loss of tolerance to environmental antigens and pathological immune responses.
- No prior studies investigated the impact of allergic diseases on male semen quality.
Purpose of the Study:
- To determine if allergic diseases affect semen quality in men with reproductive difficulties.
Main Methods:
- Semen quality was assessed in men with fertility issues using World Health Organization (WHO) standards.
- Patients underwent skin prick tests for common inhalation allergens.
- Statistical analysis was performed on the collected data.
Main Results:
- Of 52 patients, 46% had positive skin tests for at least one allergen.
- Sperm tail defects were significantly higher in men allergic to birch, rye, cat, alder, and grass.
- Head defects were more significant in patients allergic to Alternaria alternata.
Conclusions:
- Inhalation allergies were found to influence male semen quality.
- Further research is required to elucidate the immunological mechanisms underlying this association.
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