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Updated: Oct 7, 2025
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Real-time Imaging of Single Engineered RNA Transcripts in Living Cells Using Ratiometric Bimolecular Beacons
Published on: August 6, 2014
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A fluorogenic RNA aptamer nanodevice for the low background imaging of mRNA in living cells
Tingting Xu1, Yao Sun1, Sha Yu2
1State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China. jjzhu@nju.edu.cn.
Chemical Communications (Cambridge, England)
|January 6, 2022
Abstract:
A fluorogenic RNA aptamer nanodevice integrating an entropy-driven RNA amplifier with near-infrared (NIR) light control was developed, affording high contrast and sensitivity for imaging low-abundance mRNA in living cells. The design principle offers a new approach for developing low-background imaging systems for live-cell studies and manipulation.
