PATHOGENETIC FEATURES OF COMORBIDITY OF PRIMARY OSTEOARTHRITIS AND DISEASES WITH EXOCRINE PANCREATIC INSUFFICIENCY
I Halabitska1, L Babinets1, Y Kotsaba1
1I. Horbachevsky Ternopil National Medical University, Ukraine.
Abstract:
The aim of the study - to study the pathogenetic effects of activation of the kallikrein-kinin system on the course of primary osteoarthritis under conditions of comorbidity with gastroenterological diseases accompanied by exocrine pancreatic insufficiency.We examined 229 patients with primary osteoarthritis in comorbidity with exocrine pancreatic insufficiency at diseases of the gastrointestinal tract without exacerbation. The parameters of the kallikrein-kinin system and their influence on the course of primary osteoarthritis and comorbid nosologies of the gastrointestinal tract were studied.A statistically significant effect of kallikrein-kinin system activation on the course of the studied diseases on the conditions of comorbidity was revealed.The study results proved a significant effect of kallikrein-kinin system activation on the course of primary osteoarthritis under conditions of comorbidity with nosologies of the digestive system with exocrine pancreatic insufficiency and on the deepening of functional insufficiency of the pancreas by fecal α-elastase.
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