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Updated: Oct 7, 2025

Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System
Published on: December 21, 2016
Particulate matter-bound organic compounds: levels, mutagenicity, and health risks
Sofia Caumo1, Aleinnys B Yera2, Ana Vicente3
1Institute of Chemistry, University of São Paulo, São Paulo, 05508-000, Brazil. sofia.caumo@gmail.com.
Abstract:
Increased industrialization and consumption of fossil fuels in the Metropolitan Region of São Paulo (MRSP), Brazil, have caused a growth of the particulate matter emissions to the atmosphere and an increase in population health problems. Particulate and gaseous phase samples were collected in different short campaigns (2015, 2016, and 2017) near an urban-industrial area. Organic carbon (OC), elemental carbon (EC), polycyclic aromatic hydrocarbons (PAH), and its derivatives (nitro and oxy-PAH), n-alkanes, hopanes, and pesticides were determined. The Salmonella/microsome test confirmed the mutagenic activity of these samples. Among PAH, benzo(a)pyrene was detected as one of the most abundant compounds. Benzo(a)pyrene equivalent concentrations for PAH and nitro-PAH, and the associated risk of lung cancer, showed values above those recommended in the literature. The profile of n-alkanes confirmed the predominance of anthropogenic sources. Pesticide concentrations and estimated risks, such as the daily inhalation exposure and hazard quotient, suggest that exposure to these compounds in this area may be dangerous to human health.
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