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A Review on the Role of miR-1290 in Cell Proliferation, Apoptosis and Invasion

Soudeh Ghafouri-Fard1, Tayyebeh Khoshbakht2, Bashdar Mahmud Hussen3

  • 1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Frontiers in Molecular Biosciences
|January 10, 2022
PubMed

Insights

MicroRNA-1290 (miR-1290) plays a role in cancer development by interacting with various genes and regulating key molecular pathways. While often oncogenic, its precise role in malignancies requires further investigation.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) regulate gene expression and are implicated in biological processes.
  • miR-1290, transcribed from the MIR1290 gene, is involved in carcinogenesis.
  • It interacts with numerous protein-coding and non-coding RNAs.

Purpose of the Study:

  • To review the impact of miR-1290 on malignancy development.
  • To synthesize findings from in vitro, animal, and human studies.
  • To explore the dual role of miR-1290 in cancer.

Main Methods:

  • Literature review of in vitro studies.
  • Analysis of animal model investigations.
  • Examination of human clinical data.

Main Results:

  • miR-1290 interacts with genes like SOCS4, GSK3, and BCL2.
  • It regulates critical signaling pathways including JAK/STAT3, PI3K/AKT, Wnt/β-catenin, and NF-κB.
  • Evidence predominantly suggests oncogenic roles, but contradictory findings exist.

Conclusions:

  • miR-1290 is a significant factor in cancer development.
  • Its interactions and pathway regulations highlight its oncogenic potential.
  • Further research is needed to clarify its controversial roles in various malignancies.
Keywords:
biomarkercancerexpressionmiR-1290miRNA

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