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Dataset for dynamics and conformational changes in human NEIL2 protein analyzed by integrative structural biology

Polina V Zhdanova1,2, Alexander A Ishchenko3,4, Alexander A Chernonosov1

  • 1Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibisk, Russia.

Data in Brief
|January 10, 2022
PubMed

Keywords:
Base excision repairCD, circular dichroismDNA damageDNA glycosylasesDNA repairDTT, (2S,3S)-1,4-Bis(sulfanyl)butane-2,3-diolESI, electrospray ionizationHDX-MSHDX-MS, hydrogen-deuterium exchange mass spectrometryHEPES, 2-[4-(2-Hydroxyethyl)piperazin-1-yl]ethane-1-sulfonic acidIPTG, Propan-2-yl 1-thio-β-D-galactopyranosideLB, Lysogeny brothLC-MS, liquid chromatography–mass spectrometryMD, molecular dynamicsMDTRA, Molecular Dynamics Trajectory Reader & AnalyzerMolecular dynamicsNEIL2PDB, Protein Data BankRMSD, root-mean-square deviationSDS-PAGE, sodium dodecyl sulphate–polyacrylamide gel electrophoresisStructural dynamicsTCEP, 3,3’,3’’-Phosphanetriyltripropanoic acidhNEIL2, human endonuclease VIII-like 2 protein

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