Related Experiment Video
Updated: Oct 7, 2025
Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay
Published on: January 31, 2022
Evaluation of Corneal and Lenticular Parameters in Iron Deficiency Anemia
Hasan Kiziltoprak1, Ali Mert Kocer2, Turgay Fen3
1Department of Ophthalmology, Bingol Women's Health and Children's Hospital, Bingol, Turkey.
Objectives:
The aim of this study was to investigate the effects of iron deficiency anemia on corneal and lenticular densitometry.
Methods:
Thirty-two patients with iron deficiency anemia and 38 healthy participants were enrolled. The Pentacam HR imaging system (Oculus Optikgeräte GmbH, Wetzlar, Germany) was used to record keratometry, corneal densitometry (12-mm corneal diameter), lens densitometry measurements. Endothelial parameters were evaluated using specular microscopy.
Results:
The corneal densitometry values in the anterior 0-2 mm and 2-6 mm zone were significantly higher in the iron deficiency anemia group than in the control group (p=0.044 and p=0.021, respectively). There was a statistically significant difference in the mean values of the standard deviation and maximum lens densitometry measurements of the iron deficiency anemia group when compared with the control group (p=0.012 and p=0.011, respectively). There were statistically significant correlations between the anterior 2-6 mm zone corneal densitometry and ferritin, iron, and total iron binding capacity (r=-0.275, r=-0.243, r=0.240, respectively). However, ferritin, iron, and total iron binding capacity showed no significant correlation with the lens densitometry values (p>0.05 for all).
Conclusion:
Iron deficiency anemia had several effects on corneal and lenticular densitometry measurements. Evaluation of the corneal and lenticular changes at an ophthalmology clinic might be recommended for patients with iron deficiency anemia.
