In-Situ-Bloomed Micrometer-Scale Ultrathin Nanosheets in Tumor-Microenvironment for Intensive Photothermal-Enhanced...

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Materials Science

Background:

• Chemodynamic therapy (CDT) efficacy is limited by insufficient hydroxyl radical generation due to restricted reactive sites on nanoagents.
• Nanoagent size and surface area limitations hinder the full exposure of reaction sites to intracellular H2O2.

Purpose of the Study:

• To develop micrometer-scale CoMn-LDH ultrathin nanosheets from CMB@ss-SF nanospheres for enhanced photothermal-enhanced CDT.
• To improve hydroxyl radical generation and cancer treatment efficacy by increasing reactive sites.

Main Methods:

• Synthesis of CoMn boride-based CMB@ss-SF nanospheres that bloom into CoMn-LDH ultrathin nanosheets in the tumor microenvironment (TME).
• Utilizing overexpressed glutathione (GSH) and dissolved oxygen in TME to trigger nanosheet formation and accelerate Fenton-like reactions.
• Employing 808 nm light for photothermal enhancement and photoacoustic imaging (PAI).

Main Results:

• Micrometer-scale CoMn-LDH nanosheets provide abundant reactive sites, accelerating both heterogeneous and homogeneous Fenton-like reactions for enhanced ·OH generation.
• The nanoagent demonstrated efficient GSH depletion, metal ion release, and synergistic photothermal-enhanced CDT.
• Complete tumor eradication in mice with negligible cytotoxicity was achieved, showcasing superior biodegradability in the TME.

Conclusions:

• The developed CMB@ss-SF nanoagent effectively overcomes the limitations of traditional CDT nanoagents by blooming into micrometer-scale nanosheets.
• This approach significantly enhances CDT efficacy through increased reactive sites and photothermal effects.
• The study presents a promising strategy for developing advanced nanoagents for effective cancer therapy.