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[Pharmacokinetics of propofol as an induction agents in adults]
A Landais1, I D Cockshott, M C Coppens
1Département d'Anesthésie-Réanimation, Centre Hospitalier d'Argenteuil, Paris.
Cahiers D'Anesthesiologie
|October 1, 1987
Abstract:
The disposition kinetics of Propofol have been determined in 7 patients (3 men, 4 women) receiving 2.5 mg/kg for induction of anaesthesia. Peripheral venous samples were collected up to 12 hours after injection of the drug. Data analysis indicates a 3 compartment model with a terminal half-life of 480 +/- 141 min, clearance of 0.0352 +/- 0.0014 l/min/kg and volume of distribution of 24.2 +/- 6.2 l/kg.