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Similarities and differences between bone quality parameters, trabecular bone score and femur geometry
Kyong Young Kim1, Kyoung Min Kim2,3
1Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon, South Korea.
Plos One
|January 11, 2022
Summary
Image-based bone quality assessments, Trabecular Bone Score (TBS) and femur cortical thickness, show differing relationships with age and BMI. Discordance between these measures may indicate varied fracture risks.
Area of Science:
- Osteoporosis research
- Medical imaging analysis
- Bone densitometry
Background:
- Bone quality, alongside quantity, is crucial for bone strength.
- Non-invasive assessment of bone quality utilizes image-based parameters.
- Trabecular Bone Score (TBS) evaluates trabecular bone, while femur geometry assesses cortical bone.
Purpose of the Study:
- To investigate associations between TBS and femur cortical geometry.
- To explore differences in these relationships concerning age and body mass index (BMI).
Main Methods:
- Dual-energy X-ray absorptiometry (DXA) for areal bone mineral density (BMD).
- iNsight software for TBS assessment.
- APEX system for femur geometry analysis.
- Analysis included 452 men and 517 women (≥50 years).
Main Results:
- Both TBS and cortical thickness negatively correlated with age, more strongly in women.
- TBS showed negative correlation with BMI (>25 kg/m²), while cortical thickness showed positive correlation across all BMI ranges.
- Significant correlation existed between TBS and cortical thickness, but discordance was observed in approximately one-third of participants.
Conclusions:
- Image-based bone quality parameters for trabecular and cortical bone share similarities but also exhibit distinct associations with age and BMI.
- Divergent profiles of TBS and femur cortical thickness may lead to varied risk profiles for vertebral or hip fractures in certain individuals.
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