Acute tubulointerstitial nephritis in two sisters with simultaneous uveitis in one

Tubulointerstitial nephritis uveitis syndrome (TINU) is an underdiagnosed entity, defined by association of uveitis and TIN with no evidence of concomitant systemic disease that might present with both ocular and renal manifestations. Although not common, it needs awareness and collaborations of pediatricians and ophthalmologists for prompt diagnosis and treatment. The exact pathogenesis of the disease is poorly understood, and it predominantly affects female adolescents. Since its early description at 1975, many cases have been reported but only a few were familial case reports. Herein, we report TIN in two sisters, first one with uveitis (TINU) and second one, eight years later at the same age without uveitis.