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P50 Sensory Gating in Infants
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Selective 5HT3 antagonists and sensory processing: a systematic review.

Eirini Tsitsipa1, Jonathan Rogers1,2, Sebastian Casalotti1

  • 1Division of Psychiatry, University College London, 149 Tottenham Court Road, London, W1T7NF, UK.

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
|January 12, 2022
PubMed
Summary
This summary is machine-generated.

Selective serotonin (5HT3) receptor antagonists, including ondansetron, effectively improved sensory gating in schizophrenia patients. This finding supports their potential therapeutic role in psychosis by addressing sensory processing deficits.

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Area of Science:

  • Neuroscience
  • Psychopharmacology

Background:

  • Selective serotonin (5HT3) receptor antagonists, like ondansetron, are being investigated for schizophrenia and Parkinson's disease hallucinations.
  • Preclinical studies show these antagonists can reverse sensory gating deficits and enhance visuoperceptual processing in psychosis models.

Purpose of the Study:

  • To systematically review human studies on the effects of 5HT3 receptor antagonists on sensory gating and processing.
  • To assess the replication of preclinical findings in human subjects.

Main Methods:

  • Systematic review of 11 eligible human studies.
  • Studies included patients with schizophrenia and healthy participants.
  • Sensory gating assessed via P50 suppression; visuoperceptual and sensorimotor functions also evaluated.

Main Results:

  • A consistent finding was the improvement of sensory gating in schizophrenia patients treated with ondansetron and tropisetron.
  • Tropisetron also enhanced sustained visual attention in non-smoking patients.
  • Evidence for effects on other sensory processing measures was inconsistent, limited by study heterogeneity and confounding factors.

Conclusions:

  • Selective 5HT3 receptor antagonists demonstrate strong evidence for improving sensory gating in patients with schizophrenia.
  • Further research is needed in antipsychotic-naive patients to clarify clinical implications for neurocognitive symptoms.