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Construction of a sequentially responsive nanocarrier for chemotherapy and cascade amplified NIR photodynamic therapy
Tao Yan1, Linlin Ren1, Fengyan Li1
1College of Chemistry and Chemical Engineering, Linyi University, P. R. China. songxinyue428@163.com.
Chemical Communications (Cambridge, England)
|January 12, 2022
Abstract:
A sequentially responsive nanocarrier was fabricated with three-in-one functional integration: bio-imaging, tumor microenvironment responsive chemotherapy and cascade activation of upconversion photodynamic therapy. The designed DNA outer nanoshell displayed site-specific degradation and controlled degradation speed. Significantly, the developed controllable nanotheranostic agent displayed high cell apoptosis ratios and obvious tumor inhibition.
