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Delivery Pathways to the Lysosome

Delivery Pathways to the Lysosome

Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...

Lysosomes

Lysosomes

Lysosomes are membrane-enclosed spherical sacs derived from the Golgi apparatus. The most important function of the lysosome is degrading macromolecules and biological polymers that are released during membrane trafficking events such as the secretory, endocytic, autophagic, and phagocytic pathways. The degradation is carried out by several hydrolytic enzymes active in an acidic environment of the lysosomal lumen. These acid hydrolases are involved in cellular processes such as cell signaling,...

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Lysosome-Targeting Strategy Using Polypeptides and Chimeric Molecules.

Basudeb Mondal¹, Tahiti Dutta¹, Abinash Padhy¹

¹Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, Nadia, West Bengal 741246, India.

|January 17, 2022

Summary

This summary is machine-generated.

This review explores lysosome-targeting peptides and nanocarriers for treating diseases like lysosomal storage disorders and cancers. These strategies enhance cellular degradation and offer future therapeutic applications.

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Area of Science:

Cell Biology
Biochemistry
Drug Delivery

Background:

Lysosomes are crucial for cellular degradation, and their dysfunction is linked to diseases like cancer and neurodegeneration.
Lysosomal dysfunction contributes to various pathological conditions, including storage disorders, neurodegeneration, and aging.

Purpose of the Study:

To review strategies for synthesizing lysosome-targeting peptides and chimeric molecules.
To discuss the application of these molecules and nanocarriers in treating lysosomal-associated diseases.
To explore the potential of chimeric architectures for targeted protein degradation.

Main Methods:

Review of synthesis strategies for peptides and chimeric molecules.
Analysis of lysosome-targeting ligand-decorated nanocarriers for cargo delivery.
Discussion of chimeric molecule design for protein degradation.

Main Results:

Peptides and nanocarriers demonstrate lysosome-targeting capabilities.
Lysosome-targeting strategies show potential for treating lysosomal storage diseases and cancers.
Chimeric molecules can be engineered for specific protein degradation.

Conclusions:

Lysosome-targeting peptides, nanocarriers, and chimeric molecules offer promising therapeutic avenues.
Targeted delivery and degradation within lysosomes represent a key area for future research.
These approaches hold potential for treating a range of lysosomal-associated pathologies.