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Updated: Oct 6, 2025
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Three new cassane-type diterpenoids from Caesalpinia sinensis
Yuan-Kai Chen1,2, Miao-Yin Fan1, Ya-Mei Zhang1
1Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
Abstract:
Three new cassane-type diterpenoids, namely, (4S)-6β,12α,19-trihydroxy-cass-13(15)-en-16,12-olide (1), cass-13(15)-en-16,12-olide (2), and 12α-hydroxy-cass-13(15)-en-16,12-olide (3), were isolated from the seeds of Caesalpinia sinensis. The structures of 1-3 were established by extensive spectroscopic analysis, and their absolute configurations were assigned by electronic circular dichroism (ECD) calculations. The inhibitory activities against PTP1B of the isolated compounds were evaluated. The results showed that compound 2 possessed PTP1B inhibitory activity with an IC50 value of 217.45 ± 36.4 μM.
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