Streptomycin sulphate microspheres: dissolution rate studies and release kinetics. I

Area of Science:

• Pharmaceutical Sciences
• Drug Delivery Systems
• Biomaterials Science

Background:

• Drug targeting aims to enhance efficacy and reduce side effects by concentrating medication at specific sites.
• Microspheres, nanoparticles, and liposomes are advanced carriers for targeted drug delivery.
• Streptomycin sulphate, an antibiotic, is a key treatment for tuberculosis.

Purpose of the Study:

• To investigate the influence of cross-linking and matrix material on streptomycin sulphate microsphere release characteristics.
• To optimize microsphere formulations for enhanced lung accumulation and sustained drug release.
• To evaluate the kinetic profiles of streptomycin sulphate release from various microsphere formulations.

Main Methods:

• Formulation of streptomycin sulphate-loaded microspheres using human serum albumin and gelatin (Type B) as matrix materials.
• Cross-linking of microspheres with 2,3-butanedione and formaldehyde at varying concentrations and durations.
• In vitro drug release studies to assess the release profiles and kinetic behavior of different formulations.

Main Results:

• Streptomycin sulphate release exhibited a biphasic pattern: an initial burst release followed by a slower, sustained release phase.
• Modifications in cross-linking extent/nature and matrix material composition significantly impacted the slow release phase.
• Kinetic analysis revealed distinct release profiles influenced by formulation parameters.

Conclusions:

• Cross-linking and matrix material selection are critical factors in controlling streptomycin sulphate release from microspheres.
• Optimized microsphere formulations hold potential for targeted lung delivery in tuberculosis therapy.
• Understanding release kinetics is essential for designing effective drug delivery systems for antibiotics.