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Updated: Oct 6, 2025
Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
Published on: November 17, 2015
Solid lipid nanoparticles loaded with curcumin: development and in vitro toxicity against CT26 cells
Rayane Ganassin1,2, Victor Carlos Mello da Silva1,2, Victor Hugo Sousa Araujo1,2
1Laboratory of Nanoscience & Immunology, Faculty of Ceilandia, University of Brasilia, Brasilia/DF, 72220-900, Brazil.
Abstract:
Aim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma (CT26) cells in vitro was analyzed by confocal microscopy. Results: Stable SLN-Cs with a high curcumin-loading capacity were obtained. The SLN-Cs were more toxic to CT26 than free curcumin. Fluorescence microscopy images showed the SLN-Cs to be taken up by CT26 cells in vitro. Conclusion: These results indicate that SLN-Cs are suitable carriers of curcumin in aqueous media.
