Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Predictive Validity of Hypothesized Risk Factors for Superior Canal Dehiscence Syndrome.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2026
Same author

Chronic Rhinosinusitis and Nasal Polyps in Eosinophilic Granulomatosis With Polyangiitis: A Scoping Review.

International forum of allergy & rhinology·2026
Same author

The 'Prostate Cancer Screening for People at Genetic Risk of Aggressive Disease' (PATROL) study.

BJU international·2026
Same author

Spatiotemporal Medicare Reimbursement Trends and Economic Clusters in Otologic/Neurotologic Surgery.

The Laryngoscope·2026
Same author

Anthropometric Measurements Inform Complete Concentric Collapse Status in Patients With Obstructive Sleep Apnea.

OTO open·2026
Same author

Diagnostic Performance of the Stenvers and Pöschl Planes on CT in the Evaluation of Superior Semicircular Canal Dehiscence.

AJNR. American journal of neuroradiology·2026

Related Experiment Video

Updated: Oct 6, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.3K

Does Perioperative Testosterone Predict Post-Prostatectomy Genomic Risk Score?

Mohammed Shahait1, Joseph G Cheaib2, Elai Davicioni3

  • 1Department of Surgery, King Hussein Cancer Center, Amman, Jordan.

The Journal of Urology
|January 20, 2022
PubMed
Summary

This study found no significant link between preoperative testosterone levels and genomic risk scores in prostate cancer patients. Low testosterone was associated with higher odds of secondary treatment, but not recurrence.

Keywords:
biomarkersprostatic neoplasmstestosterone

More Related Videos

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

16.7K
Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
07:34

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

823

Related Experiment Videos

Last Updated: Oct 6, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.3K
Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
13:19

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Published on: November 2, 2013

16.7K
Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
07:34

Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking

Published on: November 17, 2023

823

Area of Science:

  • Oncology
  • Genomics
  • Endocrinology

Background:

  • The role of endogenous testosterone in prostate cancer development is not fully understood.
  • The impact of testosterone on the prostate cancer genome requires further exploration.

Purpose of the Study:

  • To investigate the correlation between perioperative testosterone levels and genomic risk scores in men undergoing radical prostatectomy.
  • To examine the association between testosterone levels and gene expression signatures in prostate tumors.

Main Methods:

  • Retrospective analysis of patients who underwent radical prostatectomy between 2013-2018 with adverse pathological features.
  • Assessment of serum testosterone levels and genomic risk scores (low, intermediate, high).
  • Analysis of 188 gene expression signatures and secondary outcomes including biochemical recurrence and treatment receipt.

Main Results:

  • The median genomic risk score was lower in the low testosterone group (0.38) compared to intermediate (0.52) and normal (0.53) groups (p=0.049).
  • No significant difference in biochemical recurrence-free survival was observed across testosterone groups (p=0.9).
  • Patients with low testosterone had higher odds of receiving secondary treatment (OR: 2.27; p=0.02).
  • 43 gene expression signatures were associated with testosterone levels, including 12 in DNA repair pathways.

Conclusions:

  • This study is the first to correlate preoperative testosterone levels with the tumor transcriptome.
  • No clinical correlation was found between genomic risk score groups and testosterone groups.
  • Findings suggest a limited role for endogenous testosterone in the development of de novo high-risk localized prostate cancer.