MicroRNAs in Obesity-Associated Disorders: The Role of Exercise Training

Area of Science:

• Molecular Biology
• Genetics
• Physiology

Background:

• Obesity is a global epidemic linked to cardiovascular disease and metabolic disorders.
• It arises from complex interactions between genetic and environmental factors.
• MicroRNAs (miRNAs) are key gene regulators with emerging roles in disease pathogenesis.

Purpose of the Study:

• To review the role of miRNAs in the obese phenotype and associated comorbidities.
• To explore the impact of exercise training on miRNA regulation in obesity.
• To highlight the potential of circulating miRNAs as biomarkers for obesity and cardiovascular diseases.

Main Methods:

• Literature review of recent discoveries on miRNAs in obesity.
• Analysis of molecular pathways involved in obesity and miRNA regulation.
• Discussion of exercise interventions and their effects on miRNA expression.

Main Results:

• miRNAs are implicated in the development of obesity and its comorbidities.
• Circulating miRNAs show promise as stable biomarkers for obesity and cardiovascular disease.
• Exercise training modulates specific miRNAs, suggesting a role in metabolic health.

Conclusions:

• miRNAs are critical regulators in obesity and associated cardiovascular and skeletal muscle disorders.
• Circulating miRNA profiles may serve as novel diagnostic and prognostic biomarkers.
• Exercise interventions represent a promising strategy for modulating miRNA expression and managing obesity.