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Cyclic Vomiting Syndrome-Related Hospitalizations Trends, Comorbidities & Health Care Costs in Children: A Population

Aravind Thavamani1, Krishna Kishore Umapathi2, Jasmine Khatana3

  • 1Division of Pediatric Gastroenterology, Hepatology and Nutrition, UH Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH 44106, USA.

Children (Basel, Switzerland)
|January 21, 2022
PubMed

Insights

Cyclical Vomiting Syndrome (CVS) hospitalizations in children are linked to more comorbidities and rising healthcare costs. Improved management of CVS and related conditions is crucial for better outcomes and cost reduction.

Area of Science:

  • Pediatric Gastroenterology
  • Healthcare Economics
  • Public Health

Background:

  • Cyclical Vomiting Syndrome (CVS) is a debilitating condition in children.
  • Understanding the clinical characteristics and healthcare burden of pediatric CVS is essential.

Purpose of the Study:

  • To analyze clinical features, hospitalization trends, and healthcare resource utilization for pediatric patients diagnosed with CVS.
  • To compare CVS patients with age/gender-matched controls regarding comorbidities and outcomes.

Main Methods:

  • Utilized 5 Healthcare Cost and Utilization Project-Kids Inpatient Database (HCUP-KID) datasets from 2003-2016.
  • Analyzed hospitalizations for patients aged 1-20 with a primary CVS diagnosis.
  • Compared CVS patients to matched controls for comorbidities, outcomes, and resource utilization.

Main Results:

  • 12,396 CVS hospitalizations were analyzed; mean age was 10.4 years.
  • CVS was strongly associated with dysautonomia, dyspepsia, GERD, migraines, IBS, cannabis use, anxiety, and stress disorders.
  • Inflation-adjusted hospitalization costs for CVS more than doubled from $3199 (2003) to $6721 (2016), totaling $84 million annually.

Conclusions:

  • Hospitalized pediatric patients with CVS exhibit higher rates of DGBIs, dysautonomia, psychiatric conditions, and cannabis use.
  • CVS hospitalizations in the US incur significant and increasing healthcare costs.
  • Effective management of CVS and its comorbidities is necessary to mitigate healthcare expenditures and enhance patient outcomes.
Abstract

Keywords:
comorbiditiescyclic vomiting syndromehealth care resource utilizationpopulation-based analysis

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