Related Experiment Video
Updated: Oct 6, 2025
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
11.7K
Isolated Systolic Blood Pressure and Red-Complex Bacteria-A Risk for Generalized Periodontitis and Chronic Kidney
Jaideep Mahendra1, Plato Palathingal2, Little Mahendra3
1Department of Periodontics, Meenakshi Ammal Dental College and Hospital, Chennai 600 095, Tamil Nadu, India.
Microorganisms
|January 21, 2022
Summary
Isolated systolic hypertension and red-complex bacteria are linked to generalized periodontitis and chronic kidney disease. Older adults with both conditions showed higher blood pressure and poorer kidney function, indicating increased health risks.
Area of Science:
- Periodontology
- Nephrology
- Cardiovascular Medicine
Background:
- Hypertension is a known risk factor for generalized periodontitis (GP) and chronic kidney diseases (CKD).
- The specific role of isolated systolic blood pressure (ISBP) in these inflammatory conditions remains under-explored.
- Limited research exists on the association between red-complex bacteria (RCB) and ISBP.
Purpose of the Study:
- To investigate the relationship between ISBP, RCB, demographic, periodontal, and renal parameters in patients with GP and CKD.
- To assess bacterial profiles in subgingival plaque samples across different health groups.
Main Methods:
- A study involving 120 participants (30-70 years) divided into four groups: control, GP, CKD, and CKD + GP.
- Measurements included demographic data, periodontal parameters, blood pressure (ISBP), and renal function markers (serum creatinine, eGFR, fasting blood sugar).
- Red-complex bacteria (RCB) were quantified in subgingival plaque using RT-PCR.
Main Results:
- Older participants (above 50) in the CKD + GP group exhibited worse periodontal scores, elevated ISBP, higher serum creatinine, and fasting blood sugar.
- The CKD + GP group showed significantly decreased eGFR and higher RCB counts compared to other groups.
- ISBP and RCB demonstrated significant correlations with renal and periodontal parameters, indicating a log-linear relationship.
Conclusions:
- Isolated systolic hypertension and red-complex bacteria are significantly associated with generalized periodontitis and chronic kidney disease.
- The findings suggest a higher risk for developing GP and CKD in individuals with elevated ISBP and RCB presence.
- A complex interplay exists between periodontal disease, CKD, RCB, and isolated systolic hypertension levels.
Related Concept Videos
01:25Chronic Kidney Disease I: Introduction
101
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
101
01:18Hypertension and Regulation of Blood Pressure
3.3K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.3K
01:29Hypertension II: Pathophysiology
133
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
133
01:30Hypertension III: Clinical Manifestations and Diagnostic Studies
69
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
69
01:28Special considerations while measuring blood pressure
856
When assessing blood pressure (BP), healthcare professionals must consider various factors and potential unexpected outcomes to ensure accurate readings and provide proper patient care. Adhering to these guidelines is essential to achieving the most reliable results.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
856
01:24Chronic Kidney Disease II: Clinical Manifestations
136
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
136