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Updated: Oct 6, 2025

Synthesis of Esters Via a Greener Steglich Esterification in Acetonitrile
Published on: October 30, 2018
KPF6-Mediated Esterification and Amidation of Carboxylic Acids
Sonam1, Vikki N Shinde1, Anil Kumar1
1Department of Chemistry, Birla Institute of Technology & Science, Pilani Campus, Pilani, Rajasthan 333031, India.
Abstract:
A novel KPF6-promoted green method has been developed for the synthesis of esters and amides. A wide range of carboxylic acids and alcohols or amines worked well under the developed reaction conditions, thus providing good to excellent (61-98%) yields of the corresponding esters and amides. The method worked well with bioactive substrates such as cholesterol, levulinic acid, and linoleic acid. Wide substrate scope, operational simplicity, scalability, and sustainability make this protocol a practical and economically attractive approach for the preparation of ester and amides.
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