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Self-Bonded Hydrogel Inverse Opal Particles as Sprayed Flexible Patch for Wound Healing
Li Wang1,2,3, Lingyu Sun1, Feika Bian1
1Department of Rheumatology and Immunology, Institute of Translational Medicine, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
ACS Nano
|January 24, 2022
Summary
This study introduces self-bonded hydrogel particles for wound healing. Sprayed as a patch, these particles release drugs and change color to monitor healing progress.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Nanotechnology
Background:
- Wound healing is a critical area in regenerative medicine, with ongoing efforts to develop advanced wound dressings.
- Existing wound patches aim to accelerate tissue regeneration and improve healing outcomes.
- Functional wound patches require innovative materials for effective drug delivery and monitoring.
Purpose of the Study:
- To develop self-bonded hydrogel inverse opal particles for use as a sprayed flexible wound healing patch.
- To investigate the controlled drug release and in-situ monitoring capabilities of these particles.
- To evaluate the potential of these multifunctional particles in clinical wound management.
Main Methods:
- Fabrication of inverse opal scaffolds using hyaluronic acid methacryloyl (HAMA) and gelatin methacryloyl (GelMA) doped with graphene oxide quantum dots (GO QDs).
- Infusion of drug-loaded gelatin (GT) and carrageenan (CG) pregel into the scaffolds.
- Utilizing near-infrared (NIR) irradiation for photothermal conversion by GO QDs, inducing GT/CG liquid transformation and particle self-bonding into a flexible patch.
- Monitoring drug release through visual structural color shifting due to refractive index changes.
Main Results:
- Successfully created self-bonded hydrogel inverse opal particles that form a flexible patch upon NIR irradiation.
- Demonstrated controlled drug release from the hydrogel matrix following the phase change.
- Observed visual structural color changes indicating drug release, enabling real-time monitoring.
- Validated the efficacy of the sprayed particles for wound tissue healing in preliminary assessments.
Conclusions:
- Self-bonded hydrogel inverse opal particles offer a novel approach to wound healing patches.
- The sprayed particle system allows for controlled drug delivery and visual monitoring of the healing process.
- These multifunctional particles show significant potential for clinical applications in wound management and regenerative medicine.
