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Very Long-Term Clinical Outcomes After Direct Stenting in Patients Presenting With ST-Segment Elevation Myocardial
Paola Scarparo1, Riccardo Improta1, Jeroen Wilschut1
1Department of Interventional Cardiology, Thoraxcenter, Erasmus University Medical Centre, Rotterdam, the Netherlands.
Insights
Direct stenting (DS) in ST-segment elevation myocardial infarction (STEMI) patients significantly reduces 15-year all-cause mortality. This benefit was most pronounced in patients with initial TIMI flow of 0-1, showing improved long-term outcomes.
Area of Science:
- Cardiology
- Interventional Cardiology
- Clinical Outcomes Research
Background:
- Direct stenting (DS) may reduce distal embolization and improve reperfusion in ST-segment elevation myocardial infarction (STEMI).
- The very long-term impact of DS on clinical outcomes in STEMI patients remains incompletely understood.
Purpose of the Study:
- To evaluate the very long-term clinical outcomes associated with Direct Stenting (DS) compared to conventional stenting (CS) in patients with STEMI.
Main Methods:
- A cohort of 812 STEMI patients undergoing percutaneous coronary intervention between 2002-2004 were divided into DS and CS groups.
- Major adverse cardiac events (MACE) were assessed at 10 years, and all-cause mortality at 15 years.
- Cox proportional hazards models and landmark analysis at 2 years were employed to analyze outcomes, stratified by initial TIMI flow.
Main Results:
- At 15-year follow-up, DS was associated with significantly lower all-cause mortality (35.0% vs. 45.3%, p=0.010).
- Landmark analysis revealed reduced 2-year MACE in the DS group (6.8% vs. 14%, p=0.015), with no significant difference thereafter.
- In patients with baseline TIMI flow 0-1, DS showed significantly lower 10-year MACE and 15-year mortality.
Conclusions:
- Direct stenting is associated with reduced 15-year all-cause mortality in STEMI patients.
- DS also demonstrated a reduced mid-term MACE rate, particularly beneficial for patients with initial TIMI flow of 0-1.
Background/Purpose:
Direct Stenting (DS) could be associated with reduced distal embolization and improved reperfusion in patients with ST-segment elevation myocardial infarction (STEMI). However, the impact of DS on long-term outcomes remains unclear, therefore we evaluated the impact of DS on very long-term clinical outcome in STEMI.
Methods/Materials:
Between April 2002 and December 2004, patients presenting with STEMI undergoing percutaneous coronary intervention were investigated. The study population was divided into two groups: DS and conventional stenting (CS) and stratified according to initial TIMI flow. Major adverse cardiac events (MACE) were assessed at 10 years and all-cause mortality at 15 years. Cox proportional hazards models were used. When the proportional hazards assumption was not satisfied, landmark analysis at mid-term (2 years) was performed.
Results:
A total of 812 consecutive patients were evaluated, 6 patients were excluded due to inadequate angiographic images, 450 (55.8%) underwent DS and 356 (44.2%) CS. At 15 years follow-up, DS was associated with a reduction in all-cause mortality (DS 35.0% vs. CS 45.3%, aHR 0.74, 95% CI 0.58-0.93, p = 0.010). The landmark analysis at 2 years identifies reduced 2-year MACE in DS compared with CS (6.8% vs.14%, aHR 0.67, 95% CI 0.49-0.93, p = 0.015) and beyond 2 years no significant differences were found between the groups (27.4% vs. 29.3%, aHR 1.00, 95% CI 0.74-1.36, p = 0.999). In patients with baseline TIMI 0-1, DS was associated with lower 10-year MACE and 15-year mortality compared with CS (aHR0.71, 95%CI 0.55-0.92, p = 0.010 and aHR0.65, 95%CI 0.50-0.84, p = 0.001, respectively).
Conclusions:
DS was associated with reduced 15-year all-cause mortality and reduced mid-term MACE rate in patients with STEMI. Clinical events reduction associated with DS was particularly relevant in patients with initial TIMI flow 0-1.
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