Genetic Polymorphism of Matrix Metalloproteinase-9 and Susceptibility to Myocardial Infarction: A Meta-Analysis

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Beili Feng1,2, Hengdong Li1,2

  • 1Department of Cardiology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China.

Disease Markers
|January 25, 2022
PubMed
Abstract

Insights

The MMP-9 rs3918242 CC genotype is associated with a lower risk of myocardial infarction (MI). This genetic variant, matrix metallopeptidase-9 rs3918242, shows potential relevance to MI susceptibility, particularly in Asian populations.

Area of Science:

  • Genetics
  • Cardiovascular Disease
  • Molecular Biology

Background:

  • Inconsistent findings exist regarding the association between MMP-9 rs3918242 and myocardial infarction (MI) susceptibility.
  • Matrix metallopeptidase-9 (MMP-9) plays a role in cardiovascular health.
  • Polymorphisms in MMP-9 may influence MI risk.

Purpose of the Study:

  • To conduct a meta-analysis to clarify the relationship between MMP-9 rs3918242 and susceptibility to MI.
  • To consolidate existing evidence on the genetic association of MMP-9 rs3918242 with MI.
  • To investigate the role of MMP-9 rs3918242 in MI risk.

Main Methods:

  • A systematic literature search was performed in PubMed, Cochrane Library, CNRI, and VIP.
  • Keywords included "MMP-9", "matrix metallopeptidase-9", "myocardial infarction", "acute myocardial infarction", "AMI", and "polymorphism".
  • Data from 10 eligible studies were extracted and analyzed using RevMan 5.3 and STATA12.0 to calculate odds ratios (OR) and 95% confidence intervals (CI).

Main Results:

  • The CC genotype of MMP-9 rs3918242 was associated with lower MI susceptibility compared to CT&TT genotypes (OR = 1.49, 95%CI = 1.19-1.86, P = 0.0004).
  • Significant associations were found in overdominant (OR = 1.27, 95%CI = 1.14-1.41, P < 0.0001) and allele genetic models (OR = 1.43, 95%CI = 1.17-1.74, P = 0.0005).
  • These findings were consistent in the Asian population.

Conclusions:

  • The mutation on MMP-9 rs3918242 demonstrates a potential relevance to MI susceptibility.
  • The CC genotype may confer a protective effect against myocardial infarction.
  • Further research into MMP-9 rs3918242's role in cardiovascular disease is warranted.

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