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Circulating miR-29b decrease in response to sarcopenia in patients with cardiovascular risk factors in older Chinese.

Nana He1,2, Yuelin Zhang3, Yue Zhang3

  • 1Medical Data Center, Ningbo City First Hospital, Ningbo, Zhejiang, China.

Frontiers in Cardiovascular Medicine
|January 6, 2023
PubMed
Summary

Cardiovascular risk factors like hypertension and dyslipidemia are linked to a higher prevalence of sarcopenia in elderly Chinese individuals. Circulating miR-29b levels may serve as a biomarker for sarcopenia and cardiovascular disease assessment.

Keywords:
CVRFbiomarkercirculating microRNAselderlysarcopenia

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Area of Science:

  • Gerontology
  • Cardiology
  • Molecular Biology

Background:

  • Sarcopenia, a decline in muscle mass and function, often coexists with cardiovascular diseases (CVDs), increasing patient mortality.
  • MicroRNAs (miRNAs) are emerging regulators in aging-related sarcopenia and CVDs, with potential diagnostic and therapeutic applications.

Purpose of the Study:

  • To investigate the association between cardiovascular risk factors (CVRF) and sarcopenia in the elderly Chinese population.
  • To identify circulating miRNAs as potential biomarkers for sarcopenia in patients with CVRF.

Main Methods:

  • Assessed CVRF (diabetes, hypertension, dyslipidemia) and their correlation with sarcopenia using logistic and linear regression in elderly Chinese individuals.
  • Measured plasma levels of miR-29b, miR-181a, and miR-494 in 93 control and sarcopenia subjects via real-time RT-PCR.

Main Results:

  • CVRF were associated with a higher prevalence of sarcopenia, with hypertension and dyslipidemia showing significant links.
  • Sarcopenia prevalence increased linearly with the number of CVRF components.
  • Plasma miR-29b levels were significantly downregulated in sarcopenic elderly individuals with CVRF, correlating with appendicular skeletal muscle mass.

Conclusions:

  • Hypertension and dyslipidemia are significant predictors of sarcopenia risk in the elderly.
  • Circulating miR-29b shows potential as a biomarker for sarcopenia diagnosis and monitoring treatment response, and may aid in CVD assessment.