Related Experiment Video
Updated: Oct 5, 2025

Assessing the Putative Anticryptococcal Properties of Crude and Clarified Extracts from Mollusks
Published on: December 2, 2022
Two New Cytotoxic Decalin Derivatives from Marine-Derived Fungus Talaromyces sp
Gaoran Liu1,2, Ruiyun Huo1,2, Shubin Niu3
1State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, P. R. China.
Abstract:
Two new decalin derivatives named fusarielins O (1) and P (2), together with seven known compounds (3-9) were isolated from the crude extract of the marine-derived fungus Talaromyces sp. The planar structures of the new compounds were elucidated by comprehensive spectroscopic analyses of NMR and HR-ESI-MS. The absolute configuration of 1 was assigned by Snatzke's method and comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1-9 were evaluated for their cytotoxic activities against three tumor cell lines and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities.
Related Concept Videos
Drugs that Destabilize Microtubules
Drugs that Stabilize Microtubules
Cytotoxic T Cells-mediated Immune Response
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

