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Mefenamic acid solid dispersions: Impact of formulation composition on processing parameters, product properties and

Elke Prasad1, John Robertson1, Gavin W Halbert1

  • 1EPSRC Future Manufacturing Research Hub in Continuous Manufacturing and Advanced Crystallisation, University of Strathclyde, Technology and Innovation Centre, 99 George Street, Glasgow G1 1RD, UK; Strathclyde Institute for Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK.

International Journal of Pharmaceutics
|January 27, 2022
PubMed
Summary

Developing immediate release Mefenamic acid (MFA) crystalline solid dispersions (CSD) via hot-melt extrusion (HME) showed drug loading impacts process and product performance. Higher MFA loading improved CSD consistency, while lower loading yielded faster drug release.

Keywords:
DissolutionExtrusionFormulationOral drug deliverySolid dispersionSolid dosage form

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