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A Minireview of Microfluidic Scaffold Materials in Tissue Engineering
Anh Tong1, Roman Voronov1,2
1Otto H. York Department of Chemical and Materials Engineering, Newark College of Engineering, New Jersey Institute of Technology, Newark, NJ, United States.
Frontiers in Molecular Biosciences
|January 28, 2022
Summary
Microfluidic scaffolds offer a promising solution for organ bio-manufacturing, addressing limitations in current tissue engineering. This review highlights advancements in biomaterials and fabrication for these innovative scaffolds.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Tissue Engineering
Background:
- Organ transplantation demand significantly exceeds donor availability, necessitating advanced bio-manufacturing solutions.
- Conventional scaffold technologies have limitations in creating viable artificial tissues and organs.
- Microfluidic scaffolds present a novel approach to overcome challenges in complex 3D cell culture.
Purpose of the Study:
- To review the latest progress in biomaterial design for microfluidic scaffolds.
- To summarize advancements in fabrication methods for microfluidic scaffolds.
- To highlight the potential of microfluidic scaffolds in organ bio-manufacturing.
Main Methods:
- Review of recent literature on microfluidic scaffold biomaterials and fabrication.
- Analysis of material properties required for microfluidic scaffold applications.
- Summary of 3D printing and cross-linking techniques for scaffold manufacturing.
Main Results:
- Microfluidic scaffolds enable precise control over cell microenvironments and automated in-situ manipulations.
- Ideal biomaterials for microfluidic scaffolds require biocompatibility, biodegradability, flexibility, photo-crosslinkability, and transparency.
- Progress has been made in developing suitable biomaterials and light-based 3D printing fabrication methods.
Conclusions:
- Microfluidic scaffolds show significant potential for advancing organ bio-manufacturing.
- Further development in biomaterial science and fabrication techniques is crucial for realizing this potential.
- These scaffolds can address key challenges in metabolite distribution, waste clearing, non-invasive sampling, and process standardization.
