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Development and autoregulation of kidney function in children: a retrospective study using 99mTc-MAG3 renography

Xinhua Cao1, Xiaoyin Xu2, S Ted Treves2

  • 1Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA. xinhua.cao@childrens.harvard.edu.

Pediatric Nephrology (Berlin, Germany)
|January 29, 2022
PubMed

Insights

In children with asymmetric kidneys, a healthy kidney compensates for the diseased one, maintaining up to 94% of normal total kidney function. This autoregulation is crucial for understanding kidney disease development and treatment in pediatric patients.

Area of Science:

  • Pediatric Nephrology
  • Renal Physiology
  • Diagnostic Imaging

Background:

  • Kidney function development in healthy children and autoregulation in asymmetric kidneys are clinically significant but understudied.
  • Understanding these processes aids in diagnosing and treating kidney-related diseases.

Purpose of the Study:

  • To investigate kidney function development in healthy children.
  • To assess the autoregulation of healthy kidneys compensating for diseased ones in children with asymmetric kidneys.

Main Methods:

  • Utilized 99mTc-MAG3 renography in 237 children (0-20 years).
  • Developed a kidney function (MAG3 clearance) developmental model for normal children.
  • Defined clearance autoregulation rate as the ratio of measured MAG3 clearance to the predicted normal value.

Main Results:

  • Established a developmental model for MAG3 clearance (CL) in normal children: CL = 84.39Age^0.395 (r=0.957, p<0.001).
  • Found no significant difference in MAG3 clearance between children with asymmetric kidneys and normal children.
  • The average autoregulation rate in children with asymmetric kidneys was 94.2%, with no significant variations based on age, sex, or kidney laterality.

Conclusions:

  • Healthy kidneys in children with asymmetric kidneys can autoregulate to achieve approximately 94% of the total kidney function observed in healthy children with symmetric kidneys.
  • This autoregulation capacity is a key finding for managing pediatric kidney conditions.
Abstract

Keywords:
99mTc-MAG3AutoregulationKidney functionPediatricRenal developmentRenography

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