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COMPARATIVE ANALYSIS OF CLINICAL AND LABORATORY CHARACTERISTICS OF MEASLES IN VACCINATED AND UNVACCINATED CHILDREN IN
Valentyna I Ilchenko1, Liudmyla M Syzova1, Каteryna V Pikul1
1POLTAVA STATE MEDICAL UNIVERSITY, POLTAVA, UKRAINE.
Insights
Measles vaccination significantly reduces disease severity in children. Vaccinated children experience less fever, fewer Koplik's spots, and shorter hospital stays, indicating vaccine effectiveness.
Area of Science:
- Pediatrics
- Infectious Diseases
- Immunology
Background:
- Measles remains a significant public health concern globally.
- Vaccination is the most effective preventive measure against measles.
- Understanding the clinical course in vaccinated vs. unvaccinated populations is crucial for public health strategies.
Purpose of the Study:
- To characterize the clinical and laboratory features of measles.
- To compare the disease course in vaccinated and unvaccinated children in Ukraine's Poltava region.
Main Methods:
- A study of 104 pediatric measles inpatients (27 vaccinated, 77 unvaccinated).
- Data collection included clinical assessment, patient history, medical record analysis, and peripheral blood studies.
- Statistical analysis was performed using SPSS 17.0.
Main Results:
- Vaccinated children showed significantly reduced fever (p=0.001) and fewer Koplik's spots (p=0.051).
- The duration of fever (p=0.001), cough (p=0.000), and hospital stay (p=0.000) were shorter in vaccinated children.
- Leukopenia was 3 times less common (p=0.043) and accelerated ESR 2 times less common (p=0.023) in vaccinated individuals.
Conclusions:
- The findings underscore the importance of comprehensive measles vaccination education.
- Increased public access to free vaccination through procurement is recommended.
- The study highlights the protective effect of measles vaccination on disease severity.
Objective:
The aim: To study the clinical and laboratory characteristics of measles, as well as to compare the course of this disease in vaccinated and unvaccinated children in the Poltava region (Ukraine).
Patients And Methods:
Materials and methods: 104 inpatients with measles were examined: vaccinated (n=27) and unvaccinated (n=77). The patient examination program included: assessment of complaints and anamnestic data obtained by questioning (during admission to hospital treatment, during treatment and after discharge) and detailed analysis of medical records (Form № 003/у), physical examination, general clinical study of peripheral blood. Statistical processing of the study results was carried out by methods of variation statistics using the program «SPSS 17.0».
Results:
Results: The clinical and laboratory picture of measles in the examined patients is typical for this disease. Measles vaccinated children are significantly less likely to have fever (р=0.001) and Koplik's spots (χ2=3.80, р=0.051), the duration of fever (р=0.001), cough (р=0.000), and the length of hospital stay (р=0.000), as well as 3.0 times less often leukopenia is detected (р=0.043) and 2.0 times less often - acceleration of ESR (р=0.023).
Conclusion:
Conclusions: The obtained data raise the question of expanding the explanatory work on the importance of a full course of preventive vaccination among children, as well as increasing the volume of public procurement of necessary drugs to increase public access to free vaccination.
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